Tel. +49 341 97 17941 / 17529 | E-Mail info@ kinderneurochirurgie-leipzig.de

Publications




The webteam of Kinderneurochirurgie-Leipzig.de is involved in many research projects. Current publications in progress focus on topics of hydrocephalus in malformations, brain edema and treatment of spinal deformities caused by spina bifida, and rare pediatric tumor entities. A main research project is hydrocephalus, brain water circulation and fluids hemostasis. A multidisciplinary research group led by Pediatric Neurosurgeons and Neuroradiologists has started their work in 2014 fusing preclinical, clinical, general scientific and theoretical disciplines. The research group will publish first results in 2015 and open an official webspace as BrainWaterAcademy Leipzig soon. Furthermore, therapy options of Boswellic Acid (Boswellia serrata, Indian Frankincense) is a current research project of Pediatric Neurosurgery. Recently a multi center-study has been initiated for congenital brain tumors and reports are in progress about complex multiloculated (multi compartment) hydrocephalus and neuroendoscopic treatment, aqueductal stenosis as well as long-term outcome of hydrocephalus patients

  • Dünger D, Krause M, Roth C, Gräfe D, Merkenschlager A, Sorge I «Do we need gadolinium-based contrast medium for brain MRI in children?» Pediatric Radiology 2018 Apr 6. doi: 10.1007/s00247-017-3999-2
  • d'Arcangues C, Schulz M, Bührer C, Thome U, Krause M, Thomale UW. „Extended Experience with Neuroendoscopic Lavage for Posthemorrhagic Hydrocephalus in Neonates.“ World Neurosurg. 2018 Aug;116:e217-e224. doi: 10.1016/j.wneu.2018.04.169.
  • S. Schob, HJ Meyer, C. Frydrychowicz, W. Müller, M. Preuss, U. Quäschling, K.-T. Hoffmann, A. Surov. “Diffusion-Weighted Imaging Predicts Cellular Density and Proliferative Activity in Primary CNS Lymphoma” PLOSOne 11(8); Aug 2016:  DOI: 10.1371/journal.pone.0161386
  • Schob S, Frydrychowicz C, Gawlitza M, Preuss M, Hoffmann KT, Surov A. «Signal intensities in preoperative MRI do not reflect proliferative activity in meningeoma» Translational Oncology 2016 9(4): 274-279
  • Voigt P, Schob S, Jantschke R, Nestler U, Krause M, Weise D, Lobsien D, Hoffmann KT, Quäschling U. „Stent-Assisted Coiling of Ruptured and Incidental Aneurysms of the Intracranial Circulation Using Moderately Flow-Redirecting, Braided Leo Stents-Initial Experience in 39 Patients.“ Front Neurol. 2017 Nov 14;8:602. doi: 10.3389/fneur.2017.00602.
  • Schob S, Weiß A, Surov A, Dieckow J, Richter C, Pirlich M, Horvath-Rizea D, Härtig W, Hoffmann KT, Krause M, Quäschling U. Elevated Surfactant Protein Levels and Increased Flow of Cerebrospinal Fluid in Cranial Magnetic Resonance Imaging. Mol Neurobiol. 2017 Dec 27. doi: 10.1007/s12035-017-0835-5
  • Schob S, Münch B, Dieckow J, Quäschling U, Hoffmann KT, Richter C, Garnov N, Frydrychowicz C, Krause M, Meyer HJ, Surov A. „Whole Tumor Histogram-profiling of Diffusion-Weighted Magnetic Resonance Images Reflects Tumorbiological Features of Primary Central Nervous System Lymphoma.» Transl Oncol. 2018 Mar 6;11(2):504-510. doi: 10.1016/j.tranon.2018.02.006.
  • Schob S, Beeskow A, Dieckow J, Meyer HJ, Krause M, Frydrychowicz C, Hirsch FW, Surov A. „Diffusion profiling of tumor volumes using a histogram approach can predict proliferation and further microarchitectural features in medulloblastoma.» Childs Nerv Syst. 2018 May 31. doi: 10.1007/s00381-018-3846-2.
  • Fehrenbach M, Nestler U, Meixenberger J, Bernhard MK, Merkenschlager A, Weise S, Krause M. «Late-oneset hydrocephalus in a child with Joubert-Syndrome: a case-report» Childs Nerv Syst 2018 Mar 5. DOI 10.1007/s00381-018-3767-0
  • Schob S, Lobsien D, Friedrich B, Bernhard MK, GebauerC, Dieckow J, Gawlitza M, Pirlich M, SaurD, Bechmann I, Braeuer L, Hoffmann KT, Nestler U, Preuss M. “The Cerebral Surfactant System and it’s alteration in hydrocephalic conditions” PLOS One 2016 Sep 22; 11(9): e0160680
  • Schob S, Dieckow J, Fehrenbach M, Peukert N, Weiss A, Kluth D, Thome U, Quäschling U, Lacher M, Preuß M. “Occurrence and colocalization of surfactant proteins A, B, C and D in the developing and adult rat brain.” Ann Anat. 2017 Mar; 210: 121-127. pii: S0940-9602(16)30184-4.
  • Schob S, Weiß A, Dieckow J, Richter C, Pirlich M, Voigt P, Surov A, Hoffmann KT,Quäschling U, Preuß M «Correlations of Ventricular Enlargement with Rheologically Active Surfactant Proteins in Cerebrospinal Fluid» Frontiers Aging Neurosci 2017 Jan 4; 8: 324.
  • Krause M, Peukert N, Härtig W, Emmer A, Mahr CV, Richter C, Dieckow J, Puchta J, Pirlich M, Hoffmann KT, Nestler U, Schob S. „Localization, Occurrence, and CSF Changes of SP-G, a New Surface Active Protein with Assumable Immunoregulatory Functions in the CNS.» Mol Neurobiol. 2018 Jul 21. doi: 10.1007/s12035-018-1247-x
  • Rodis I, Mahr CV, Fehrenbach MK, Meixensberger J, Merkenschlager A, Bernhard MK, Schob S, Thome U, Wachowiak R, Hirsch FW, Nestler U, Preuss M. “Hydrocephalus in aqueductal stenosis – a retrospective analysis and proposal of subtype classification” Childs Nerv Syst 2016, February 27
  • Mahr CV*, Dengl M*, Nestler U, Reiss-Zimmermann M, Eichner G, Preuss M (corresponding author), Meixensberger J. “Idiopathic Normal Pressure Hydrocephalus – Diagnostic and predictive value of clinical testing, lumbar drainage and CSF dynamics” JNS 2016, 29 Jan.
  • Fehrenbach M, Bernhard MK, Siekmeyer M, Lippmann N, Kiess W, Meixensberger J, Preuss M. “VP-shunt dysfunction caused by malaria CNS infection” Childs Nerv Syst 2015 Sep 22
  • Kutscher A, Nestler U, Bernhard MK, Merkenschlager A, Thome U, Kieß W, Schob S, Meixensberger J, Preuss M  “Adult long-term health-related quality of life of congenital hydrocephalus patients” Journal of Neurosurgery (Pediatrics) 2015 Sep. 4: 1-5
  • Preuß M, Preiss S, Syrbe S, Nestler U, Fischer L, Merkenschlager A, Bertsche A, Christiansen H, Bernhard MK. „Signs and symptoms of pediatric brain tumors and diagnostic value of preoperative EEG“ Childs Nerv Syst 2015; 31(11): 2051-54. DOI: 10.1007/s00381-015-2842-z
  • Weise S, Syrbe S, Preuss M, Bertsche A, Merkenschlager A, Bernhard MK. "Pronounced reversible hyperammonemic encephalopathy associated with combined valproate-topiramate therapy in a 7-year-old girl." Springerplus. 2015 Jun 17;4:276. doi: 10.1186/s40064-015-1057-9. eCollection 2015.
  • Ivkovic M, Reiss-Zimmermann M, Katzen H, Preuss M, Kovanlikaya I, Heier L, Alperin N, Hoffmann KT, Relkin N. "MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic normal pressure hydrocephalus." Fluids Barriers CNS. 2015 Apr 2;12:9. doi: 10.1186/s12987-015-0004-z.
  • Preuss M, Christiansen H, Merkenschlager A, Hirsch FW, Kiess W, Müller W, Kästner S, Henssler A, Pekrun A, Hauch H, Nathrath M, Meixensberger J, Pietsch T, Kuchelmeister K. "Disseminated oligodendroglial cell-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity." J Neurooncol. 2015 Feb 12
  • Preuss M, Kutscher A, Wachowiak R, Merkenschlager A, Bernhard MK, Reiss-Zimmermann M, Meixensberger J, Nestler U. "Adult long-term outcome of patients after congenital hydrocephalus shunt therapy." Childs Nerv Syst. 2014 Oct 17
  • Stummer W, Rodrigues F, Schucht P, Preuss M, Wiewrodt D, Nestler U, Stein M, Artero JM, Platania N, Skjøth-Rasmussen J, Puppa AD, Caird J, Cortnum S, Eljamel S, Ewald C, González-García L, Martin AJ, Melada A, Peraud A, Brentrup A, Santarius T, Steiner HH; For the European ALA Pediatric Brain Tumor Study Group. „Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey.“ Acta Neurochir 2014 Sept 24
  • Preuß M, Thome U, Kluge J, Hirsch FW, Viehweger A, Nestler U. "Retroclival arachnoid cyst in a preterm infant after ventriculitis and intraventricular hemorrhage-a case report." Childs Nerv Syst. 2014 Aug 10.
  • Preuss M, Werner P, Barthel H, Nestler U, Christiansen H, Hirsch FW, Fritzsch D, Hoffmann KT, Bernhard MK, Sabri O. "Integrated PET/MRI for planning navigated biopsies in pediatric brain tumors." Childs Nerv Syst. 2014 Apr 8.
  • Preuss M, Hirsch W, Hoffmann KT, Bernhard MK, Siekmeyer M, Kiess W, Meixensberger J, Wurm RE, Merkenschlager A. "Effectiveness of bevacizumab for radiation-induced cerebral necrosis in children." Pediatr Neurosurg. 2013;49(2):81-5. doi: 10.1159/000357447
  • Preuss M, Steinhoff A, Zühlke CJ, Schulz D, Stein M, Nestler U, Christophis P. "Pathophysiology and treatment options in trigeminal meningoceles." J Neurol Surg Rep. 2013 Dec;74(2):81-7. doi: 10.1055/s-0033-1348955.
  • U. Nestler, D. Memia-Zolo, N. Salloum, M. Mejdoubi, F. Lengelle, R. Santiago, W. Cécile, R. Stegaru and N. Manzo, "Sinogenic Subdural Empyema in a Ten-Year-Old Boy with Sickle Cell Anemia," Open Journal of Modern Neurosurgery, Vol. 3 No. 4, 2013, pp. 53-58. doi: 10.4236/ojmn.2013.34012.
  • Preuss M, Hoffmann KT, Reiss-Zimmermann M, Hirsch W, Merkenschlager A, Meixensberger J, Dengl M. "Updated physiology and pathophysiology of CSF circulation - The pulsatile vector theory" Childs Nerv Syst 2013 July; DOI: 10.1007/s00381-013-2219-0
  • Nestler U, Wagner HJ, Schaenzer A, Preuss M. “Solid variant of Aneurysmal Bone Cyst of the left frontal bone without preceding trauma” J Neurol Surg A Cent Eur Neurosurg 2012, Sep 26.
  • Evangelou P, Meixensberger J, Bernhard M, Hirsch W, Kiess W, Merkenschlager A, Nestler U, Preuss M. "Operative management of idiopathic spinal intradural arachnoid cysts in children: A systematic review" Childs Nerv Syst 2013  April; 29(4): 657-664.
  • Preuss M, Renner C, Krupp W, Christiansen H, Fischer L, Merkenschlager A, Kieß W, Müller W, Manzo N, Meixensberger J, Nestler U. "The use of 5-aminolevulinic acid fluorescence guidance in resection of pediatric brain tumors" Childs Nerv Syst. 2013. DOI: 10.1007/s00381-013-2159-8 http://link.springer.com/article/10.1007%2Fs00381-013-2159-8
  • Preuß M, Evangelou P, Hirsch W, Reiss-Zimmermann M, Fischer L, Merkenschlager A, Kieß W, Siekmeyer M, Meixensberger J, Nestler U. "Acute two-compartment low pressure hydrocephalus--a case report." Childs Nerv Syst. 2013 Dec;29(12):2307-10. doi: 10.1007/s00381-013-2173-x.
  • Preuss M, Stein M, Neubauer BA, Schaaf H, Howaldt HP, Nestler U, Christophis P. “About the operative Management and postoperative Neural Development of Patients with Cloverleaf Skull Deformity” Childs Nerv Syst. 2010 Sep;26(9): 1211-8.
  • Preuss M. „A energy-failure based brain edema concept“ Medical Hypotheses 2012 May 79:259-60.
  • Preuss M, Heckmann M, Stein M, Nestler U. “Two cases of Walker-Warburg Syndrome complicated by hydrocephalus” Pediatr Neurosurg 2010 May 27;46(1):34-38
  • Preuss M, Nestler U, Zühlke CJ, Kuchelmeister K, Neubauer BA, Joedicke A. “Progressive biological behaviour of a Dysembroplastic Neuroepithelial Tumor” Pediatr Neurosurg 2010 Dec 30;46: 294-298
  • Preuss M, Zühlke CJ, Hahn A, Stein M, Nestler U. “Traumatic left lateral C2 epiphysiorhexis in a three-year-old girl. A case Report” Eur J Pediatr Surg 2011 Dec;21(6): 412-414.
  • Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DK. Boswellic acids inhibit glioma growth: a new treatment option? J Neurooncol. 2000;46(2):97-103